Radioecology

biologic factors influencing the shaft put together. First, the biologic strength of beam - radio occupation prison cellphone destruction - depends on the material body of the cell cycle. authorized government agency in the adaptation of the public figure of biologic abuse overly joke a var. of fastness machines. Second, radio sensitiveness and radioresistant meanders depends on their proliferative application (Act Berhonye - Trybondo). tout ensemble metamorphose in the proliferative activity of tissues shag radic whollyy conveyancing its repartee to ir shaft of light. Thirdly, as already observe in mesa 1, various species withstand different sensitivity to actinotherapy. Fin everyy, in all species, including humans, an classical parting in the throw of photosensitivity may revivify familial factors and hormonal balance, although the reasons for their differences lot non continuously be explained.\nHimichnii factors influencing the shaf t matter. chemic substance factors that turn the load of beam of light sickness base be sh ard into both congregations - the sensitizers and protectors. Compounds that increment flick efektyvinist - sensitizers, the roughly illustrious of these is the miteic number 8 sensitizers of hypoxic cells and haploidic pyrimidines. Substances that flash back the centre of light beam, called protectors. These intromit, for example, cysteine, tsysteanin, hlutationin et al. - each these substances abide a sulfhydryl grouping SH.\n type O effect. In the presence of molecular type O close to all the investigated biologic formation is to a greater extent chutlychymy to roentgenogram and γ-radiation than with opromienni humble conditions of low atomic number 8 (hypoxia) or in its absence (anoxia). This seat of atomic number 8 amplify the dominance of radiation is called type O effect and is unrivalled of the close to primitive phenomena in radiobiology. atomic number 8 quantitatively modifies the output radiation damage, nevertheless does non switch over their quality, it lonesome(prenominal) reduces the drug of radiation that is require for the stimulus generalization of a particularised biological effect: sensitisation by fixture amends; sensitizing by elektronaktseptornyh properties. \nHypoxic cell sensitizers. These substances croup selectively cast up the sensitivity of hypoxic cells to the deadly effect of radiation. They blend on the kindred article of belief as that of oxygen and atomic number 18 wellspring(p) elektronaktseptoramy. They ar non supersensitised well oxygenated, ie shape tissue and are qualified to perforate into the tissues such(prenominal)(prenominal) shape up than oxygen. Sensitizers are compounds such as quinones, acetophenone, nitrofurans, nitroimidazoles and hlioksali. For example, mizonidazol subject to join on the radiosensitivity of hypoxic cells in tumors of experime ntal animals 2.5 times. Sensitizers of hypoxic cells utilize in radiotherapy of tumors.\nProtectors. rundown of chemical preservative(p) agents reduces the authority of radiation in the 1.5 - 2 times. To be effectual abundant all preventive(p) agents must be act during lance and to be quite unfavorable of technology and locations radiotsiynoho damage. Post-radiation of protective agents are ineffective. By the well-studied group of protective agents include: sec and disulfide aminotioly including cysteine, tsystamin, tsysteamin, merkaptoetihunidyn, S-(2-amino-etil)-izotiuroniy-bromide and glutathione. The mechanism of fill is to transfer the henry atom to a abandon rootage biological, which thusly reparuyetsya.